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國立陽明大學神經科學研究所
從分子到認知
林慶波 教授

林慶波 教授(專任)

cplin@ym.edu.tw

Tel:+886-2-2826-7338

Fax:+886-2-2826-2285

相關聯結:http://bclab.ym.edu.tw/

 

成員

吳青芳 黃明浩 劉一萱 張舜泰 林尚樺 黃俊肇

研究簡介

磁振造影技術(MRI),因其非侵入性的優點,使其得以在各相關領域蓬勃發展,本實驗室則是利用更新穎的擴散磁振造影(diffusion MRI)技術,不但將其應用在心理、生理、醫學方面,並著重於技術的發展,以期將傳統MRI及dMRI技術,更廣泛地應用在更多領域。

在心理學領域的研究中,我們將MRI與TMS、MEG、EEG等技術整合,探索不同情境下的人體反應與行為,所對應的大腦功能區為何。MRI不僅可以非侵入性的方式,得取高解析度的解剖影像,並可利用dMRI技術,顯示組織中的微小結構。藉由TMS,不同的大腦功能區因此可加以定位,而透過MEG及EEG對大腦信號傳遞的紀錄,我們更可瞭解大腦在活化後,如何將訊號傳遞到相對應的反應區。結合以上技術,將更有助我們對大腦功能及其結構的深刻瞭解。
在生理結構的研究上,我們採用dMRI技術,來突顯組織的微細結構,如大腦中的神經纖維網路。利用dMRI中的FA及ADC參數,將其與病人的病症作統計分析,這有助於病症的判斷。
在醫學的研究上,dMRI可用於腫瘤病人的術前診斷,並預測術後的回復狀況。同時,透過正常受試者及ADHD病人間的差異比較,不需藉由測定或醫師經驗的診斷,就能輕易發現病人的變化。此外,由dMRI發展出的神經纖維追蹤(Tractography / Fiber Tracking)技術,則有助觀察神經纖維的復原,及幹細胞在大腦中的作用。其他如中風、大腦的創傷與此技術的結合,也在進行中。
在工程研究上,我們發展了神經纖維追蹤(Tractography / Fiber Tracking)技術、擴散譜磁振造影(DSI)技術。DSI,相對於傳統的dMRI技術,又提供了更多組織結構上的資訊。其他如大腦影像的自動化分割(Automatic Segmentation)技術、建立蒙地卡羅模型(Monte-Carlo Simulation Model)在擴散現象的應用、DSI在神經纖維密度的研究、以及dMRI與反應時間的相關研究結合、虛擬實境及其他工具軟體的發展也如火如荼的進行中。相信未來能夠對醫學以及生物領域有更大的幫助。
 
論文
 

Chun-Yi Lo, Pei-Ning Wang, Kun-Hsien Chou, Jinhui Wang, Yong He*, Ching-Po Lin*. 2010 “Diffusion tensor tractography reveals abnormal topological organization in structural cortical networks in Alzheimer’s disease” Journal of Neuroscience (In press).

Kun-Hsien Chou, Yawei Cheng, I-Yun Chen, Ching-Po Lin*, Woei-Chyn Chu *. 2010 “Sex-Linked White Matter Microstructure of the Social and the Analytic Brain” NeuroImage (In press).

Kuen-Jer Tsai, Chun-Hung Yang, Yen-Hsin Fang, Kuan-Hung Cho, Wei-Lin Chien, Wei-Ting Wang, Tzu-Wei Wu, Ching-Po Lin, Wen-Mei Fu, Che-Kun James Shen. 2010 “Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U” Journal of Experimental Medicine (In press).

Wei-Ta Chen, Shuu-Jiun Wang, Jong-Ling Fuh, Ching-Po Lin, Yu-Chieh Ko, Yung-Yang Lin. 2010 “Persistent ictal-like visual cortical excitability in chronic migraine” Pain (In press).

Yawei Cheng, Chen-Yi Chen, Ching-Po Lin, Kun-Hsien Chou, Jean Decety. 2010 “Love hurts: an fMRI study” NeuroImage 51(2): 923-929.

B. B. Biswal, M. Mennes, X. Zuo, S. Gohel, C. Kelly, S. M. Smith, C. F. Beckmann, J. S. Adelstein, R. L. Buckner, S. Colcombe, A. Dogonowski, M. Ernst, D. Fair, M. Hampson, M. J. Hoptman, J. S. Hyde, V. J. Kiviniemi, R. K尒ter, S. Li, C. P. Lin, M. J. Lowe, C. Mackay, D. J. Madden, K. H. Madsen, D. S. Margulies, H. S. Mayberg, K. McMahon, C. S. Monk, S. H. Mostofsky, B. J. Nagel, J. J. Pekar, S. J. Peltier, S. E. Petersen, V. Riedl, S. A. Rombouts, B. Rypma, B. L. Schlaggar, S. S. Seidler, G. J. Siegle, C. Sorg, G. Teng, J. Veijola, A. Villringer, M. Walter, L. Wang, X. Weng, S. Whitfield-Gabrieli, P. Williamson, C. Windischberger, Y. Zang, H. Zhang, F. X. Castellanos, M. P. Milham, 2010 “Towards discovery science of human brain function” Proceedings of the National Academy of Sciences 107:4734-4739.

Chun-Hung Yeh, J.-Donald Tournier, Kuan-Hung Cho, Ching-Po Lin*, Fernando Calamante, Alan Connelly. 2010 “The Effect of Finite Diffusion Gradient Pulse Duration on Fibre Orientation Estimation in Diffusion MRI” NeuroImage 51: 743-751.

Yawei Cheng, Kun-Hsien Chou, I-Yun Chen, Yang-Teng Fan, Jean Decety, Ching-Po Lin*. 2010 “Atypical Development of Frontal Fractional Anisotropy in Adolescents with Autism Spectrum Disorder” NeuroImage, Apr; 50(3): 873-882.

Erick Jorge Canales-Rodríguez+, Ching-Po Lin+, Yasser Iturria-Medina, Chun-Hung Yeh, Kuan-Hung Cho, Lester Melie-Garcia. 2010 “Diffusion Orientation Transform Revisited” NeuroImage, Jan 15; 49(2): 1326-39.

Cheng-Ta Li, Ching-Po Lin*, Kun-Hsien Chou, I-Yun Chen, Jen-Chuen Hsieh, Chia-Liang Wu, Wei-Chen Lin, Tung-Ping Su*. 2010 “Structural and cognitive deficits in remitted and non-remitted recurrent depression: A voxel based morphometric study” NeuroImage, 50: 347–356.

Ke-Hsin Chen, Hsin-Ya Fan, Su-Ping Tsao, Yi-Ping Chao, Ching-Po Lin*. 2010 “Probabilistic Language Pathways Based HARDI Tractography” Chinese Journal of Magnetic Resonance, 27(3):1-8.

Yu-Ming Chuang, Wanyuo Guo, Ching-Po Lin. 2010 “Appraising the Plasticity of the Circle of Willis: A Model of Hemodynamic Modulation in Cerebral Arteriovenous Malformations” European Neurology, 63: 295–301.
 
Yi-Ping Chao, Kuan-Hung Cho, Chun-Hung Yeh, Kun-Hsien Chou, Jyh-Horng Chen, Ching-Po Lin*. 2009 “Probabilistic topography of human corpus callosum using cytoarchitectural parcellation and HARDI-tractography” Human Brain Mapping, Oct; 30(10): 3172-87.
 
Kuan-Hung Cho, Chun-Hung Yeh, Jyh-Horng Chen, Ching-Po Lin*. 2009 “Potential in reducing scan times of HARDI by accurate correction of the cross-term in a hemi-spherical encoding scheme” Journal of Magnetic Resonance Imaging, Jun; 29(6): 1386-94.
 
Wei-Che Lin, Cheng-Hsien Lu, Yu-Chang Lee, Hung-Chen Wang, Chun-Chung Lui, Yu-Fan Cheng, Yi-Ting Shih, Ching-Po Lin*. 2009 “White matter damage in carbon monoxide intoxication assessed in vivo using diffusion tensor MRI” American Journal of Neuroradiology, Jun; 30(6): 1248-55.
 
Meng-Rui Lee, Yu-Ming Chuang, Wen-Jone Chen, Ching-Po Lin. 2009 “Meticulous blood pressure control is mandatory for symptomatic primitive trigeminal artery” Am J Emerg Med, 27 (5) pp. 634.e5-7.
 
Wei-Ta Chen, Shuu-Jiun Wang, Jong-Ling Fuh, Ching-Po Lin, Yu-Chieh Ko, Yung-Yang Lin. 2009 “Peri-ictal Normalization of Visual Cortex Excitability in Migraine: an MEG Study” Cephalalgia, 29: 1202-1211.
 
Xiujuan Geng, Thomas J. Ross, Wang Zhan, Hong Gu, Yi-Ping Chao, Ching-Po Lin, Gary E. Christensen, Norbert Schuff, Yihong Yang. 2009 “Diffusion MRI registration using orientation distribution functions” Inf Process Med Imaging 21: 626-37.
 
Yu-Ming Chuang, Ching-Po Lin, Ho-Fai Wong, Yeu-Jhy Chang, Chien-Hung Chang, Ting-Yu Chang, Tai-Cheng Wu, Hsiu-Chuan Wu, Tsong-Hai Lee. 2009 “Plasticity of Circle of Willis: A longitudinal Observation of Flow Patterns in the circle of Willis One Week After Stenting for Severe Internal Carotid Artery Stenosis” Cerebrovascular Diseases, Apr 24; 27(6): 572-578.
 
Yu-Ming Chuang, Chien-Chih Chen, Ching-Po Lin. 2009 “Vertebral artery hypoplasia may contribute to abnormal vestibular evoked myogenic potential” Acta Neurol Taiwan, Jun; 18(2): 113-7.
 
Ya Mei Bai, Kun-Hsien Chou, Ching-Po Lin*, I-Yun Chen, Cheng-Ta Li, Yang Kai Chun, Tung-Ping Su*. 2009 “White Matter Abnormalities in Schizophrenia Patients with Tardive Dyskinsia: A Diffusion Tensor Image Study” Schizophrenia Research, Apr; 109(1-3): 167-181.
 
Yawei Cheng, Kun-Hsien Chou, Jean Decety, I-Yun Chen, Daisy Hung, Ovid Jyh-Lang Tzeng, Ching-Po Lin*. 2009 “Sex Differences in the Neuroanatomy of Human Mirror-Neuron System: a Voxel-Based Morphometric Investigation” Neuroscience, Jan; 158(2): 713–720.
 
Kuan-Hung Cho, Chun-Hung Yeh, Jacques-Donald Tournier, Yi Ping Chao, Jyh-Horng Chen*, Ching-Po Lin*. 2008 “Evaluation of the accuracy and angular resolution of Q-ball imaging” NeuroImage, Aug 1; 42(1): 262-271.
 
J-Donald Tournier, Chun-Hung Yeh, Fernando Calamante, Kuan-Hung Cho, Alan Connelly, Ching-Po Lin*. 2008 “Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion weighted imaging phantom data” NeuroImage, Aug 15; 42(2): 617-625.
 
Chun-Hung Yeh, Kuan-Hung Cho, Hsuan-Cheng Lin, Jiun-Jie Wang, Ching-Po Lin*. 2008 “Reduced Encoding Diffusion Spectrum Imaging Implemented with a Bi-Gaussian Model” IEEE Transactions on Medical Imaging, Oct; 27(10): 1415-24.
 
Yi-Ping Chao, Jyh-Horng Chen, Kuan-Hung Cho, Chun-Hung Yeh, Kun-Hsien Chou, Ching-Po Lin*. 2008 “A Multiple Streamline Approach to High Angular Resolution Diffusion Tractography” Medical Engineering & Physics, Oct; 30(8): 989–996.
 
Yu-Ming Chuang, Chih-Yang Liu, Po-Jung Pan, Ching-Po Lin*. 2008 “Posterior Communicating Artery Hypoplasia might Contribute to Acute Ischemic Stroke in the Absence of Carotid Artery Occlusion” Journal of Clinical Neuroscience, Dec; 15(12): 1376-1381.
 
Ching-Po Lin, Wan-Yuo Guo, Kun-Hsien Chou, Ming-Teh Chen, Min-Hsiung Chen, Yu-Shu Yen, Yi-Ping Chao, Donald Ming-Tak Ho. 2008 “Peri-tumoral Fractional Anisotropy Mapping as a Prognosticator and Treatment Guidance of Brain Tumors: A Feasibility Study” Journal of Medical and Biological Engineering, Sep; 28 (3): 139-145.
 
Yawei Cheng, Po-Lei Lee, Chia-Yen Yang, Ching-Po Lin, Jean Decety. 2008 “Gender Differences in the Mu Rhythm of the Human Mirror Neuron System” PLoS ONE, May 7; 3(5): e2113, 1-7.
 
Yawei Cheng, Chia-Yen Yang, Ching-Po Lin, Po-Lei Lee, Jean Decety. 2008 “The Perception of Pain in Others Suppresses Somatosensory Oscillations: A Magnetoencephalography Study” NeuroImage, May 1; 40(4): 1833-1840.
 
Erick J. Canales-RodríguezYasser Alemán-Gómez, Ching-Po Lin, Yasser Iturria-Medina, Pedro A. Valdés-HernándezLester Melie-García. 2008 “A Bayesian framework to identify principal intravoxel diffusion profiles based on Diffusion-Weighted MR Imaging” NeuroImage, Aug 15; 42(2): 750-770.
 
Erick Jorge Canales-RodríguezLester Melie-García, Yasser Iturria-Medina, Eduardo Martínez-MontesYasser Alemán-Gómez, Ching-Po Lin. 2008 “Inferring Multiple Maxima in Intravoxel White Matter Fiber Distribution” Magnetic Resonance in Medicine, Sep; 60(3): 616-630.
 
Jiun-Jie Wang, Yu-Chun Lin, Yau-Yau Wai, Hao-Li Liu, Ching-Po Lin, Ying-Zu Huang. 2008 “Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach” Magnetic Resonance in Medicine, 59(4): 764-70.
 
Yu-Ming Chuang, Yuan-Chung Hwang, Ching-Po Lin*, Chih-Yang Liu. 2008 “Toward A Further Elucidation: Role of Vertebral Artery Hypoplasia in Migraine with Aura” European Neurology, 59(3-4): 148-151.
 
Yu-Ming Chuang, Chih-Yang Liu, Po-Jung Pan, Ching-Po Lin*. 2007 “Anterior Cerebral Artery A1 Segment Hypoplasia May Contribute to A1 Hypoplasia Syndrome” European Neurology, Jan 19; 57(4): 208-211.
 
Yawei Cheng, Ching-Po Lin, Ho-Ling Liu, Yuan-Yu Hsu, Kun-Eng Lim, Daisy Hung, Jean Decety. 2007 “Expertise Modulates Pain Perception in Others” Current Biology, Oct 9; 17(19): 1708-1713.
 
Yawei Cheng, Jean Decety, Ching-Po Lin, Jen-Chuen Hsieh, Daisy Hung, Ovid J.L. Tzeng. 2007 “Sex differences in spinal excitability during observation of bipedal locomotion” Neuroreport, 18(9): 887-890.
 
Shih-Hwa Chiou, Chung-Lan Kao, Han-Tso Lin, Wen-Ser Tseng, Ren-Shyan Liu, Chen-Fun Chung, Hung-Hai Ku, Ching-Po Lin, Tai-Tong Wong. 2006 “Monitoring the Growth Effect of Xenotransplanted Human Medulloblastoma in Immunocompromised Mice Model Using In Vitro and Ex Vivo Green Fluorescent Protein Imaging” Childs Nervous System, 22: 485-490.
 
Ching-Po Lin, Van J. Wedeen, Ching Yao, Jyh-Horng Chen, Wen-Yih I. Tseng. 2003. “Validation of Diffusion Spectrum Magnetic Resonance Imaging with Registered Manganese-enhanced Optic Tracts and Phantom” NeuroImage, Jul; 19(3): 482-495.
 
Ching-Po Lin, Wen-Yih Isaac Tseng, Hui-Cheng Cheng, Jyh-Horng Chen. 2001. “Validation of Diffusion Tensor Magnetic Resonance Axonal Fiber Imaging with Registered Manganese-enhanced Optic Tracts” NeuroImage, Nov; 14(5): 1035-1047.
 
林慶波,大腦神經網路:凡走過必留下痕跡,2008,科學人四月刊
 
林慶波、江品儀、趙一平,擴散磁振造影之發展與應用,2008,科儀新知四月刊
 
 
 
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